Comparison of medication for ED
When spending PDE 5 inhibitors, make the patient aware that they are doing not cause a right away erection, which will not happen without sensual stimulation. This might not be obvious to the patient.
Erectile dysfunction (ang. dysfunction, ED) consistent with various sources can affect 25-35% and even 52% of men, mostly between 40 and 60 years old, but may also include young men. However, such disorders mustn’t be associated solely with the physiological aging process, as they will be a harbinger of undiagnosed diseases like coronary cardiovascular disease, hypercholesterolemia or diabetes
high vital sign and disorder (causing the arteries to narrow and harden, thus reducing blood flow to the corpus cavernosum),
diabetes (can affect both blood vessels and penile innervation)
depression (as well as many antidepressants),
increased nervous tension.
An outsized group of pharmacological agents may cause a decrease in libido and impotence, the foremost commonly used of which are: β-blockers (to a lesser extent), SSRIs (especially citalopram, fluoxetine, paroxetine), or drugs utilized in benign prostatic hyperplasia (dutasteride, finasteride).
Type 5 phosphodiesterase inhibitors
The most commonly used drugs are phosphodiesterase type 5 (PDE 5) inhibitors: cenforce, vardenafil, and vidalista. They strengthen the physiological mechanism of erection, supporting the comfort of muscles within the main male organ’s cavernous bodies. The condition for the effectiveness of medication from this group is sensual stimulation. Therefore, these drugs won’t be effective in patients who have an issue with the drive.
Cenforce
Cenforce 100 and Cenforce 200 is an exceeding dose of 25 mg, and 50 mg ( Inventum, Mensil, Maxigra Go, Maxon Forte ) is out there without a prescription. In comparison, a dose of 100 mg ( Falsigra, Viagra ) is offered on prescription. The recommended dose is 25 mg taken approximately one hour before sensuality. If necessary, your doctor may increase the amount to 100 mg. this implies that, as pharmacists, we should always not suggest using the drug in a very dose on top of 25 mg each day, although, after all, this can be standard practice.
Vidalista
Vidalista 20 is prescription-only in dosages of 5 mg ( Tadalafil ), 10 mg ( Tadalafil ), 20 mg ( Vidalista Medana ), and 25 mg ( Tadalafil ). The recommended dose is 10 mg, taken a minimum of half-hour before intercourse. If the ten mg dose doesn’t have the required effect, it is often doubled. It’s the longest duration of action compared to cenforce and vardenafil.
Vardenafil
Vardenafil in doses of 10 mg and 20 mg, within the style of coated or chewable tablets, is obtainable on prescription. The only noticeable advantage of vardenafil over cenforce is that it doesn’t alter your color perception. This can be a rare side effect of cenforce.
Comparison of PDE 5 inhibitors
The abbreviation IC 50 within the table represents the drug concentration required to inhibit 50% of PDE5. In practice, this suggests that the doses of medication can’t be compared directly by the patient. The lower the IC 50, the lower the amount the patient must view effect.
Taking cenforce and vardenafil with high-fat foods worsens their absorption, and vidalista shows no such interaction. These drugs haven’t been shown to potentiate the hypotensive effects of alcohol (in healthy volunteers), but patients should be advised to avoid large amounts of alcohol together with PDE 5 inhibitors
Alcohol consumption itself may induce potency disorders. Therefore it’s going to counteract the results of this group of medication.
Cenforce, vidalista, and Kamagra Oral Jelly shouldn’t be combined with nitrates thanks to enhancing the hypotensive effect. Contraindications to the employment of PDE5I include unstable angina, severe congestive heart condition or uncontrolled hypertension, and arrhythmias.
The most common side effects include headache, flushing, nasal congestion. There are reports on the development of PDE 5 inhibitors, deterioration of vision, hearing, or the event of melanoma. Still, the present data confirm the effectiveness, tolerability, and safety of PDE5 inhibitors within the treatment of dysfunction.
When spending PDE 5 inhibitors, make the patient aware that they do not cause a right away erection, which’ll not happen without sensual stimulation. This might not be obvious to the patient.